Implementing a U.S. strategy for Africa that promotes the sustainable growth of African economies requires an approach focused on employing economic diplomacy at the continent level. Economic diplomacy provides a constructive way for the U.S. to positively influence African regional economic integration, the protection of human security, and African Union progression. Transnational threats, economic prosperity, and upholding a rules-based international order are issues that will continue to link African security with U.S. national security. An overarching strategy requires strong partnerships at the national level and leveraging U.S. strengths to increase pressure on great power rivals. This approach most effectively achieves African and U.S. economic and security objectives and counters the malign influence of China and Russia on the continent.